GEMpath

ANATOMY and HISTOLOGY

Anatomy of the Laboratory Mouse (hosted by the Jackson Laboratory)

http://www.informatics.jax.org/cookbook/

A collection of well-labeled diagrams from many but not all systems. The index is particularly useful as the key words are followed by hyperlinks to the relevant figures.

High Resolution Mouse Brain Atlas

http://www.hms.harvard.edu/research/brain/atlas.html#

An atlas of coronal sections from a young adult mouse, labeled to highlight neurons and myelin. A “Labels” button calls forth a larger, well annotated view.

Histology Atlas – Deltabase

http://www.deltagen.com/target/histologyatlas/HistologyAtlas.html

A database showing normal microscopic anatomy of mouse organs and tissues. Images are arranged by system. Each image is simply annotated to show basic anatomic features.

Histology Atlas – University of Illinois

http://www.med.uiuc.edu/histo/small/atlas/index.htm

An archive showing normal microscopic anatomy of organs and tissues from multiple species. The database may be searched by organ (using “Slides”) as well as by cell type or subcellular organelle (via “Objects”).

Mouse Brain Atlas

http://www.mbl.org/atlas170/atlas170_frame.html

An atlas of coronal sections from a young adult, male, C57BL/6J mouse. The “Brain Atlas” link at the bottom of the home page leads to a list of brain atlases (many still in progress) for other mouse strains, at different ages, in coronal and horizontal orientations.

Virtual Slide Box (University of Iowa)

http://www.path.uiowa.edu/virtualslidebox

An archive showing microscopic anatomy of normal and diseased organs and tissues from multiple species. The database may be searched by species, organ, and/or diagnosis. A “Comparative Search” tool allows side-by-side comparison of two images at once.

Visible Mouse

http://ccm.ucdavis.edu/tvmouse

An archive of gross and microscopic anatomy as well as functional imaging of normal and diseased organs of wild type and engineered. Many pages are still under construction, and most make heavy use of large multimedia files.

PHYSIOLOGY

Centre for Modelling Human Diseases

http://www.cmhd.ca/enu_mutagenesis/physiology_stats/physiology_stats.html

A modest list of physiological data for selected mouse organ systems.

Inbred Strain Characteristics (Jackson Laboratory)

http://www.informatics.jax.org/external/festing/mouse/STRAINS.shtml

An alphabetical portal with links to extensive biological characterizations of hundreds of inbred mouse strains. This site is a superb means of obtaining a rapid and thorough overview of strain-specific anatomy and physiology.

EMBRYOLOGY

Comparative Placentation

http://medicine.ucsd.edu/cpa/indxfs.html

An impressive site with text and images to compare placental structure among many species. The simplest means for accessing the mouse and rat data is to use the “Index” button and the scroll to the bottom to find the “Rodentia” section.

Edinburgh Mouse Atlas Project (EMAP)

http://genex.hgu.mrc.ac.uk/intro.html

A three-dimensional interactive atlas of mouse development based on extant texts describing mouse developmental anatomy and physiology (Kaufman MH 1992; Kaufman MH and Bard JBL 1999; Theiler K 1989). The database covers most of gestation and includes both reconstructed images and line drawings of various Theiler stages in conjunction with interpretive text.

Edinburgh Mouse Atlas Gene Expression (EMAGE)

http://genex.hgu.mrc.ac.uk/intro.html

A color-coded array of in situ gene expression over time, imposed on the images of embryos and extraembryonic membranes in the EMAP atlas of mouse development. Data may be evaluated for specific organs and tissues in two and three dimensions.

Embryo Images Online

http://www.med.unc.edu/embryo_images/unit-welcome/welcome_htms/akgs.htm

A three-dimensional atlas of mouse embryogenesis comprised of high resolution scanning electron micrographs, segregated by organ system. New pages under development promise to address normal fetal development and the anatomic basis of birth defects.